One-D TMS — Revolutionary Single-Day Treatment for Depression in Mt Kisco, NY
Imagine treating your depression in a single day. ONE-D TMS is a revolutionary breakthrough in interventional psychiatry that delivers a full course of transcranial magnetic stimulation in one carefully structured visit. At TMS of Westchester, we are proud to be among the first practices offering this cutting-edge protocol to patients in Mt Kisco, NY and beyond. Call (914) 241-0758 to learn more.
What Is One-D TMS?
ONE-D TMS — which stands for Optimized, Neuroplasticity-Enhanced Depression Treatment Regimen — is the latest and most condensed evolution in Accelerated TMS technology. Where conventional TMS Therapy spans six to eight weeks of daily visits and Accelerated TMS compresses treatment into five days, ONE-D TMS delivers the entire treatment course in a single day — making it a truly unprecedented development in the history of interventional psychiatry.
ONE-D TMS is designed for individuals suffering from treatment-resistant depression who want or need the fastest possible path to relief. It is supported by the latest neuroscience research and is developed from the same science behind the SAINT Accelerated TMS protocol. Clinical outcomes have been promising, with patients experiencing rapid and durable symptom relief after a single-day treatment.
How ONE-D TMS Works
The ONE-D protocol involves 20 sessions of high-intensity, 3-minute intermittent Theta-Burst Stimulation (iTBS) — the same pulse sequence used in Stanford’s SAINT protocol — delivered across the course of a single day. Each 3-minute stimulation session is followed by a 30-minute rest period, allowing the brain to recover and consolidate the neuroplastic changes triggered by each session before the next begins.
The protocol is also “Neuroplastogen-Enhanced,” meaning that prior to beginning treatment, patients receive a single pre-treatment dose of up to two supportive medications specifically chosen to boost the brain’s neuroplasticity. These agents enhance the brain’s ability to form new synaptic connections and rewire neural circuits — amplifying the therapeutic effect of each TMS session and helping produce faster, more robust results.
The total treatment day at TMS of Westchester begins in the morning and concludes in the late afternoon. During the rest intervals between sessions, patients can relax, read, listen to music, or engage in light activities in our comfortable Mt Kisco office. No sedation is required, and most patients go home the same day feeling significantly better than when they arrived.
Key Benefits of ONE-D TMS
One-Day Completion: The entire course of treatment is accomplished in a single visit — no repeat appointments required.
Rapid Symptom Relief: Based on the underlying SAINT science, patients may begin experiencing meaningful symptom reduction within hours to days of treatment.
Low Side Effect Profile: ONE-D TMS is non-invasive and does not produce the systemic side effects associated with antidepressant medications. Most patients tolerate the full-day protocol comfortably.
Neuroplasticity Enhancement: The pre-treatment neuroplastogen component is a distinguishing feature of the ONE-D protocol that enhances the brain’s capacity to benefit from each TMS session.
Ideal for Busy Professionals and Travelers: ONE-D TMS is particularly well-suited for individuals who cannot commit to a multi-week daily treatment schedule — whether due to career demands, geographic distance, or other logistical barriers.
Long-Lasting Results: Early clinical data suggests that the neuroplastic changes induced by ONE-D TMS may provide durable relief without the need for ongoing maintenance treatment.
Important Note: ONE-D TMS is currently a self-pay treatment that is not covered by insurance, and it is awaiting FDA approval at this time. Our team at TMS of Westchester will discuss all financial considerations with you transparently before beginning treatment.
Is ONE-D TMS Right for You?
ONE-D TMS may be an excellent option if you have treatment-resistant depression and have not found adequate relief from medications, conventional therapy, or standard TMS — or if you are seeking the fastest possible route to recovery with minimal disruption to your life. It is also worth considering if you have responded to Accelerated TMS in the past and are looking for a convenient maintenance option.
Contact TMS of Westchester at (914) 241-0758 or visit our New Patients page to schedule a consultation and find out whether ONE-D TMS is the right next step for your mental health journey in Mt Kisco, NY.
Frequently Asked Questions — One-D TMS
What does ONE-D stand for?
ONE-D stands for Optimized, Neuroplasticity-Enhanced Depression Treatment Regimen. The name reflects the protocol’s two core innovations: the neuroplastogen pre-treatment that enhances the brain’s capacity to benefit from stimulation, and the optimized iTBS session design that delivers a full TMS course in a single structured day.
How is ONE-D TMS different from Accelerated TMS (SAINT)?
Both ONE-D TMS and Accelerated TMS (SAINT) use intermittent theta burst stimulation and are designed for rapid relief from treatment-resistant depression. The key distinction is timeline: SAINT is delivered over five days with 8–10 sessions per day, while ONE-D TMS condenses the entire protocol into a single day with 20 sessions spaced 30 minutes apart. ONE-D also incorporates a neuroplastogen pre-treatment dose to further amplify the brain’s responsiveness.
Is ONE-D TMS FDA-approved?
ONE-D TMS is currently awaiting FDA approval. While the underlying stimulation technology (iTBS/TMS) is FDA-cleared and the science is grounded in published research including the SAINT trial, the specific ONE-D protocol as offered at TMS of Westchester has not yet received standalone FDA approval. Our team will provide full transparency about this during your consultation.
Does ONE-D TMS require any medications?
Yes — the ONE-D protocol includes a pre-treatment dose of up to two neuroplastogen agents taken before the day’s stimulation sessions begin. These are supportive medications specifically chosen to enhance the brain’s neuroplasticity and optimize the benefit of each TMS session. Our team will review these agents with you in detail during your consultation, including any relevant contraindications.
Is ONE-D TMS covered by insurance?
No. ONE-D TMS is currently a self-pay treatment not covered by insurance. This is largely because it is an emerging protocol awaiting FDA approval. Our team at TMS of Westchester will provide full transparency around the cost and help you understand all of your options before committing to treatment. For insurance-covered TMS options, see our TMS Therapy or Accelerated TMS pages.
What kind of results can I expect from ONE-D TMS?
Based on the clinical science behind the SAINT protocol and early ONE-D outcomes, many patients experience meaningful symptom relief within hours to days of their single-day treatment. Results vary by individual, and our team at TMS of Westchester will discuss realistic expectations based on your specific clinical history during your consultation.
Who is an ideal candidate for ONE-D TMS?
ONE-D TMS is best suited for adults with treatment-resistant depression who have not found adequate relief from medications, therapy, or standard TMS; those who need the fastest possible path to recovery; busy professionals or travelers who cannot commit to a multi-week daily treatment schedule; and patients who have responded to SAINT-based TMS in the past and are seeking a convenient future option. Contact TMS of Westchester at (914) 241-0758 to discuss your suitability.